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CAS NO:
101953-61-1
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ChP,
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Basic Info
CAS Number
101953-61-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Emedastine is a potent, second-generation antihistamine belonging to the piperazine class of compounds, primarily utilized for the management of allergic conjunctivitis. Its molecular formula is C20H26N4O2, and it is uniquely identified by the CAS number 105389-97-7. Structurally, emedastine dihydrogen tartrate serves as the stable salt form commonly found in pharmaceutical preparations, ensuring optimal solubility and bioavailability for ocular administration. Unlike first-generation antihistamines that readily cross the blood-brain barrier, emedastine exhibits high selectivity for peripheral H1 receptors while demonstrating minimal central nervous system penetration, thereby significantly reducing the risk of drowsiness and sedation associated with older therapeutic agents.
The primary clinical application of emedastine is the topical treatment of seasonal allergic conjunctivitis, characterized by symptoms such as itching, redness, and tearing. As an ophthalmic solution, typically formulated at a concentration of 0.05%, it provides rapid relief upon instillation into the affected eye. The drug functions by competitively inhibiting histamine binding at H1 receptors on mast cells and nerve endings, effectively blocking the inflammatory cascade triggered by allergens like pollen or pet dander. Beyond its immediate antihistaminic effects, emerging research suggests emedastine may possess mild anti-inflammatory properties, potentially stabilizing mast cell membranes to prevent further release of mediators involved in allergic reactions.
Clinical trials have consistently demonstrated the efficacy of emedastine in alleviating ocular itching within minutes of application, with effects lasting for several hours, allowing for twice-daily dosing regimens. It is generally well-tolerated, with local side effects being rare and usually limited to transient stinging or dryness. Due to its favorable safety profile and lack of systemic absorption, emedastine is considered a preferred choice for patients requiring effective allergy control without compromising daily activities or cognitive function. While not indicated for systemic allergies, its targeted delivery mechanism makes it a cornerstone therapy in modern ophthalmology for managing acute and chronic ocular allergic conditions.
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