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Preclinical Research Services

Doxapram

Category:

Preclinical Research Services

CAS NO:

3192-64-1

Standard:

ChP,

Price Range:

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Main Sales Markets:

Europe,Asia,South America,Africa,Middle East

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China National Standard Pharmaceutical Co., Ltd.

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Basic Info

CAS Number

3192-64-1

Pharmacopoeia

ChP

Grade

In-house Standards

Is Manufacturer

YES

Packaging & Delivery

Minimum Order Quantity

Any

Delivery Cycle

Negotiable

Product Description

Reference Standards &Impurity

AI Product Description

*The following content is generated by AI and is for reference only.

Doxapram is a potent respiratory stimulant belonging to the class of analeptics, primarily utilized in clinical settings to treat respiratory depression. Its chemical identity is defined by the molecular formula C20H24N2O2 and the CAS Registry Number 75-13-8. Structurally, it is an imidazole derivative that acts centrally on the medullary respiratory center in the brainstem. Unlike some older stimulants, Doxapram exerts its effect by directly increasing the sensitivity of chemoreceptors to carbon dioxide, thereby enhancing the depth and rate of breathing without significantly raising blood pressure or heart rate at therapeutic doses. The primary medical application of Doxapram is the management of postoperative respiratory depression following anesthesia, particularly when patients fail to regain spontaneous breathing after the administration of neuromuscular blockers or opioids. It is also employed in cases of drug-induced respiratory depression caused by sedatives, barbiturates, or opioid overdoses where mechanical ventilation is not immediately available or as a bridge until definitive treatment takes effect. In specific scenarios involving chronic obstructive pulmonary disease (COPD) with hypercapnia, it may be used cautiously to stimulate respiration, though its use in this context requires careful monitoring due to potential side effects. Despite its efficacy, Doxapram therapy must be administered with precision. The drug can induce adverse reactions such as hypertension, tachycardia, tremors, nausea, and vomiting if the dosage exceeds therapeutic limits. Furthermore, it is contraindicated in patients with epilepsy, severe hypertension, or acute myocardial infarction, as the increased sympathetic activity could exacerbate these conditions. Administration is typically achieved via intravenous injection or infusion, allowing for rapid onset of action within minutes. While modern critical care often favors mechanical ventilation for severe respiratory failure, Doxapram remains a valuable pharmacological tool in emergency medicine and perioperative care for reversing mild to moderate respiratory depression. Its unique mechanism ensures targeted stimulation of the respiratory drive, making it a distinct option in the arsenal of life-saving respiratory support agents.