*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Domperidone Impurity D</strong> (CAS 104789-63-5) is a synthetic byproduct of <strong>domperidone</strong> manufacturing, characterized as 2,3-dichloro-10-(2,3-dimethoxyphenyl)-1,2,3,4-tetrahydro-1H-benzimidazo[2,1-a]isoindole. Its molecular formula is C<sub>21</sub>H<sub>22</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>. This impurity arises from specific side reactions during the condensation step.</p>
<h3>Application</h3>
<ul>
<li><strong>Quality Control:</strong> Used as reference standards in HPLC method validation for pharmaceutical APIs.</li>
<li><strong>R&D:</strong> Employed in stability-indicating assays to monitor degradation pathways.</li>
<li><strong>Regulatory Compliance:</strong> Essential for ICH Q3A documentation regarding impurity thresholds.</li>
</ul>
<h3>Precautions</h3>
<p>Store under inert atmosphere at 2-8°C protected from light. Handle with appropriate PPE to avoid skin contact; strictly for research use only, not for human administration.</p>