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CAS NO:
57808-66-9
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Basic Info
CAS Number
57808-66-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Domperidone is a widely utilized pharmacological agent belonging to the class of dopamine D2 receptor antagonists. With the chemical formula C22H24ClN5O2 and the CAS Registry Number 3901-67-3, this compound plays a pivotal role in modern medicine, particularly in the management of gastrointestinal disorders. Structurally, domperidone is characterized by its benzimidazole core substituted with a chlorophenyl group and a piperidine ring, which facilitates its specific interaction with peripheral dopamine receptors.
The primary clinical application of domperidone lies in its potent antiemetic and prokinetic properties. Unlike many other dopamine antagonists that readily cross the blood-brain barrier, domperidone exhibits poor central nervous system penetration due to its polarity. This unique pharmacokinetic profile allows it to effectively treat nausea and vomiting caused by various etiologies, including chemotherapy, radiation therapy, and surgical procedures, without inducing significant sedation or extrapyramidal side effects often associated with central dopaminergic blockade. Furthermore, as a prokinetic agent, domperidone enhances gastric motility and accelerates gastric emptying. It achieves this by blocking dopamine receptors in the upper gastrointestinal tract, thereby increasing the tone of the lower esophageal sphincter and promoting coordinated peristalsis. Consequently, it is frequently prescribed for patients suffering from functional dyspepsia, gastroesophageal reflux disease (GERD), and gastroparesis, especially in cases where delayed gastric emptying contributes to symptoms like bloating, early satiety, and abdominal discomfort.
Despite its therapeutic efficacy, domperidone usage requires careful consideration regarding potential cardiac risks, such as QT interval prolongation, which has led to regulatory restrictions in certain jurisdictions. Nevertheless, when used appropriately under medical supervision, it remains a valuable tool for improving quality of life in individuals experiencing chronic digestive disturbances. Its ability to alleviate gastrointestinal symptoms while minimizing central neurological interference distinguishes it within the landscape of antiemetic therapies, making it an essential component in both acute and chronic management protocols worldwide.
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