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Other Specialized Reagents

Dolutegravir Intermediate/(R)-3-Amino-1-Butanol 61477-40-5

Category:

Other Specialized Reagents

CAS NO:

61477-40-5

Standard:

ChP,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Sinoway Industrial Co. Ltd

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Basic Info

CAS Number

61477-40-5

Pharmacopoeia

ChP

Grade

Pharmaceutical Grade

Is Manufacturer

Packaging & Delivery

Packaging Specification

25kg/bag

Minimum Order Quantity

25kg

Delivery Cycle

7 days after payment

Product Description

Product name	(R)-3-Amino-1-Butanol; Dolutegravir sodium Intermediate; Dolutegravir Intermediate
CAS No.	61477-40-5
Molecular Formula	C4H11NO
Molecular Weight	89.7314
Quality Standard	99% up
Appearance	Colorless clear liquid

AI Product Description

*The following content is generated by AI and is for reference only.

Dolutegravir Intermediate, specifically (R)-3-Amino-1-Butanol (CAS No. 61477-40-5), serves as a critical chiral building block in the pharmaceutical industry for the synthesis of advanced antiretroviral agents. This compound is characterized by its specific stereochemistry, denoted by the "(R)" configuration, which is essential for ensuring the biological efficacy and safety of the final drug product. The molecular formula for this intermediate is C4H11NO, with a precise molecular weight of approximately 89.14 g/mol. As a colorless to pale yellow liquid or low-melting solid depending on purity and storage conditions, it exhibits high solubility in common organic solvents while maintaining stability under controlled environments. The primary application of (R)-3-Amino-1-Butanol lies in its role as a key precursor in the multi-step synthesis of Dolutegravir, a potent integrase strand transfer inhibitor used globally to treat HIV-1 infection. In the manufacturing process, this chiral amine undergoes specific coupling reactions and cyclization steps to form the core bicyclic structure required for the active pharmaceutical ingredient (API). The strict requirement for optical purity in this intermediate cannot be overstated; impurities arising from the wrong enantiomer can significantly compromise the therapeutic index of the final medication. Consequently, manufacturers adhere to rigorous quality control protocols, often utilizing chiral chromatography to verify enantiomeric excess before the material proceeds to downstream processing. Beyond its direct link to Dolutegravir production, this chemical may find utility in research and development settings where novel antiviral compounds are being explored. Its availability in high-grade purity supports the scaling of clinical trials and commercial production, ensuring a steady supply chain for life-saving therapies. Due to its reactive amino and hydroxyl functional groups, it requires careful handling and storage away from strong oxidizing agents and moisture to prevent degradation. Overall, (R)-3-Amino-1-Butanol represents a vital component in modern medicinal chemistry, bridging the gap between basic organic synthesis and the delivery of effective HIV treatments to patients worldwide.