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Other Preparations
CAS NO:
114977-28-5
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Basic Info
Is Manufacturer
YES
Samples Provided
YES
Product Description
Docetaxel Injection 40 mg is a cytotoxic chemotherapy medication used in the treatment of various cancers, including breast, lung, prostate, gastric, and head & neck cancers. It works by inhibiting cell division, effectively slowing or stopping the growth of cancer cells. This injectable solution is administered under the supervision of a qualified healthcare professional.
AI Product Description
*The following content is generated by AI and is for reference only.
Docetaxel Injection 40 mg is a potent chemotherapy agent belonging to the taxane class, primarily indicated for the treatment of various solid tumors. It functions by inhibiting microtubule disassembly, thereby arresting cell division and inducing apoptosis in rapidly dividing cancer cells. This formulation is commonly prescribed for patients with locally advanced or metastatic breast cancer, non-small cell lung cancer (NSCLC), castration-resistant prostate cancer, and gastric adenocarcinoma, often in combination with other therapeutic agents like cisplatin or hormonal therapies depending on the specific clinical scenario.
The administration of Docetaxel requires strict medical supervision due to its narrow therapeutic index and potential for severe adverse reactions. Patients must undergo pre-medication with corticosteroids, such as dexamethasone, starting one day prior to infusion to significantly reduce the risk of severe hypersensitivity reactions and fluid retention. The drug is administered intravenously over a period of approximately one hour under controlled conditions. Common side effects include myelosuppression, particularly neutropenia, which increases susceptibility to infections; alopecia; peripheral neuropathy; fatigue; and nail changes. More serious complications may involve severe allergic reactions, pulmonary toxicity, and hepatic impairment.
Special precautions are essential for patients with liver dysfunction, as Docetaxel is metabolized by the cytochrome P450 system, and dosage adjustments are frequently necessary based on bilirubin levels and transaminase activity. Individuals with a history of severe hypersensitivity to Docetaxel or Cremophor EL should not receive this medication. Furthermore, pregnant women and nursing mothers must avoid exposure due to potential fetal harm. Regular monitoring of blood counts, liver function tests, and renal parameters is mandatory throughout the treatment cycle. Healthcare providers must ensure that the injection site remains free of extravasation risks, although local tissue irritation can occur. Given the complexity of its pharmacokinetics and toxicity profile, Docetaxel Injection 40 mg should only be initiated and managed by qualified oncology specialists experienced in administering cytotoxic therapy to ensure optimal patient safety and therapeutic efficacy.
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