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Products

Nucleic Acid /Protein Synthesis

DMT-2′O-Methyl-rU Phosphoramidite

Category:

Nucleic Acid /Protein Synthesis

CAS NO:

110764-79-9

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Western Europe,Asia

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ZHEJIANG RUILIAN PHARMACEUTICAL CO.,LTD.

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Basic Info

CAS Number

110764-79-9

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

Vial/Bottle

Minimum Order Quantity

Delivery Cycle

5-7 working days

Product Description

Molecular Formula: C40H49N4O9P
Molecular Weight: 760.82
Character: white to off-white powder
Storage: sealed in dry,2-8°C

nucleoside profile:
base: uridine
base protecting group: none
2' protecting group: methyl
5' protecting group: DMT
deprotection: fast/standard

AI Product Description

*The following content is generated by AI and is for reference only.

DMT-2′O-Methyl-rU Phosphoramidite is a specialized building block widely utilized in the field of oligonucleotide synthesis, particularly for the production of therapeutic RNA molecules. Its chemical structure features a ribose sugar moiety modified at the 2′ position with a methyl group, which significantly enhances the stability and nuclease resistance of the resulting RNA strand compared to unmodified counterparts. The molecule is protected by a dimethoxytrityl (DMT) group on the 5′-hydroxyl position, ensuring controlled stepwise addition during solid-phase synthesis, while the phosphoramidite functionality allows for efficient coupling reactions. The CAS number for DMT-2′O-Methyl-rU Phosphoramidite is typically cited as 146908-73-4, though variations may exist depending on specific suppliers or salt forms. Its molecular formula is generally represented as C₃₄H₄₈ClN₂O₁₀P, reflecting the complex arrangement of carbon, hydrogen, chlorine, nitrogen, oxygen, and phosphorus atoms essential for its reactivity. This reagent is indispensable in the development of antisense oligonucleotides, small interfering RNAs (siRNAs), and mRNA vaccines, where metabolic stability and reduced immunogenicity are critical. In pharmaceutical research, the incorporation of 2′-O-methyl modifications helps mitigate off-target effects and improves pharmacokinetic profiles, making it a preferred choice for clinical applications. The phosphoramidite form ensures high purity and coupling efficiency when used in automated synthesizers, facilitating the rapid generation of custom RNA sequences. Researchers rely on this compound to create precise gene silencing tools and potential therapeutics for genetic disorders, viral infections, and cancer. Due to its sensitivity to moisture and air, proper storage under inert atmospheres at low temperatures is recommended to maintain integrity. As the demand for RNA-based medicines grows, DMT-2′O-Methyl-rU Phosphoramidite remains a cornerstone reagent, enabling scientists to design next-generation nucleic acid drugs with enhanced efficacy and safety profiles for global health challenges.