【 name 】DL-10-Camphorsulfonic acid, sodium salt
【CAS NO】34850-66-3
White crystalline or crystalline powder
[Application] Central stimulant, which has the function of stimulating respiratory center and vascular movement center, is mainly used for respiratory and circulation inhibition caused by poison in central depressant and pneumonia.
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DL-10-Camphorsulfonic acid sodium salt, commonly abbreviated as Na-CSA or DL-2-camphor-10-sulfonate, is a versatile chiral auxiliary and resolving agent widely utilized in organic synthesis and pharmaceutical manufacturing. With the CAS number 13479-56-8, this compound serves as the sodium salt of (+/-)-camphorsulfonic acid, a derivative of camphor that possesses a rigid bicyclic structure essential for inducing stereoselectivity in chemical reactions. The molecular formula is C₁₀H₁₆NaO₄S, reflecting its composition of ten carbon atoms, sixteen hydrogen atoms, one sodium atom, four oxygen atoms, and a sulfur atom within the sulfonate group.
The primary application of DL-10-camphorsulfonic acid sodium salt lies in the resolution of racemic mixtures into their individual enantiomers. Due to its chirality, it forms diastereomeric salts with basic compounds, allowing for separation based on differences in solubility. This process is critical for producing optically active pharmaceuticals, agrochemicals, and fine chemicals where specific stereochemistry dictates biological activity and safety. Beyond resolution, it acts as an effective chiral catalyst or ligand precursor in asymmetric synthesis, facilitating the creation of complex molecules with high enantiomeric excess. Its solid state at room temperature ensures ease of handling and storage compared to liquid acids, while its water solubility facilitates aqueous workup procedures. In industrial settings, it is preferred for its stability and ability to withstand various reaction conditions without decomposing. Researchers frequently employ it in the development of new drug candidates to ensure regulatory compliance regarding chiral purity. Furthermore, its role extends to material science, where it aids in the synthesis of functional polymers with specific optical properties. As a reliable and cost-effective reagent, DL-10-camphorsulfonic acid sodium salt remains a staple in laboratories dedicated to advanced organic chemistry and the production of high-value chiral intermediates, bridging the gap between theoretical stereochemistry and practical industrial application.