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2557-49-5
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Basic Info
CAS Number
2557-49-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Diflorasone is a potent synthetic topical corticosteroid belonging to the fluorinated class of glucocorticoids, widely utilized in dermatological practice for its strong anti-inflammatory and antipruritic properties. Chemically known as diflorasone diacetate when formulated for clinical use, this compound features a complex steroid backbone modified with fluorine atoms at specific positions to enhance lipid solubility and receptor affinity. Its molecular formula is C24H30F2O5, reflecting its structural composition which includes two fluorine atoms that significantly increase its potency compared to non-fluorinated steroids like hydrocortisone. The substance is identified by the CAS registry number 1896-67-5, serving as a unique identifier for regulatory compliance and chemical tracking globally.
Clinically, Diflorasone is primarily indicated for the short-term management of moderate to severe inflammatory skin conditions resistant to less potent therapies. It is frequently prescribed for disorders such as psoriasis, eczema, atopic dermatitis, lichen planus, and various forms of contact dermatitis where rapid reduction of redness, swelling, and itching is required. Due to its high potency (classified as Group II or III depending on the formulation), it is typically reserved for thick-skinned areas like the palms, soles, or elbows, rather than thin-skin regions such as the face or groin, to minimize systemic absorption and local side effects. The drug functions by inhibiting the synthesis of inflammatory mediators, including prostaglandins and leukotrienes, while suppressing immune cell migration to the affected site.
Available formulations include ointments, creams, and lotions, often combined with other agents to improve patient compliance and therapeutic outcomes. While highly effective, long-term use requires careful medical supervision to prevent adverse effects such as skin atrophy, striae, telangiectasia, or hypothalamic-pituitary-adrenal axis suppression. Patients are advised to apply the medication sparingly and only for the duration specified by their healthcare provider. Overall, Diflorasone remains a cornerstone treatment in dermatology for managing stubborn inflammatory skin diseases, offering a powerful tool for restoring skin health when used responsibly within established safety guidelines.
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