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Products

Active Pharmaceutical Ingredients

Diclofenac Epolamine

Category:

Active Pharmaceutical Ingredients

CAS NO:

119623-66-4

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Shanghai Haoyuan Chemexpress Co., Ltd.

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Basic Info

CAS Number

119623-66-4

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Packaging & Delivery

Packaging Specification

Product Description

Standard :In-house Standards

AI Product Description

*The following content is generated by AI and is for reference only.

Diclofenac Epolamine is a topical pharmaceutical formulation featuring diclofenac diethylammonium salt, designed primarily for the localized treatment of acute musculoskeletal injuries and chronic inflammatory conditions. Unlike oral non-steroidal anti-inflammatory drugs (NSAIDs), this epolamine complex enhances skin penetration while significantly reducing systemic absorption, thereby minimizing gastrointestinal and cardiovascular risks associated with traditional oral therapies. The active ingredient, diclofenac, functions by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), effectively blocking the synthesis of prostaglandins that mediate pain, swelling, and inflammation. The chemical structure of the active moiety corresponds to the molecular formula C14H10Cl2NNaO2 when considering the sodium salt variant often found in related literature, though the specific epolamine salt form involves an interaction between diclofenac and diethylamine. Its CAS Registry Number is 53869-07-9, which uniquely identifies the diclofenac diethylammonium compound used in these transdermal preparations. This product is widely available as a gel or patch, commonly applied to areas such as joints affected by osteoarthritis, tendonitis, sprains, and strains. Clinical studies have demonstrated its efficacy in providing rapid relief from pain and improving joint mobility without the need for oral ingestion. The formulation typically includes excipients like carbomers, propylene glycol, and ethanol to facilitate drug delivery through the stratum corneum. By targeting the site of injury directly, Diclofenac Epolamine offers a favorable safety profile for patients who cannot tolerate oral NSAIDs due to gastric ulcers, renal impairment, or elderly status. It is indicated for short-term management of acute soft tissue injuries and long-term control of degenerative joint diseases. While generally well-tolerated, local skin reactions such as itching, rash, or dryness may occur. Users should avoid application on broken skin and adhere to prescribed dosing frequencies to prevent potential systemic accumulation. Overall, this topical agent represents a crucial therapeutic option in modern pain management strategies, bridging the gap between effective symptom relief and patient safety.