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Preclinical Research Services
CAS NO:
439-14-5
Standard:
ChP,
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Basic Info
CAS Number
439-14-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Diazepam, widely recognized by its brand name Valium, is a cornerstone medication in the benzodiazepine class of psychoactive drugs. Chemically, it possesses the molecular formula C16H13ClN2O and is identified by the CAS number 439-14-5. This synthetic compound features a tricyclic structure comprising a benzene ring fused to a diazepine ring, substituted with a chlorine atom and a methyl group, which contributes significantly to its pharmacological stability and potency.
Clinically, Diazepam serves as a versatile therapeutic agent primarily indicated for the management of anxiety disorders, acute alcohol withdrawal symptoms, muscle spasms, and certain types of seizures, including status epilepticus. Its mechanism of action involves enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) at the GABA-A receptor in the central nervous system. By facilitating chloride ion influx into neurons, it hyperpolarizes the cell membrane, thereby reducing neuronal excitability and producing calming, anxiolytic, sedative, hypnotic, anticonvulsant, and muscle relaxant effects. The drug is available in various formulations, including oral tablets, injectable solutions, and rectal gels, allowing for flexible administration depending on the urgency and nature of the condition being treated.
Due to its rapid onset and long half-life, Diazepam is particularly effective for both immediate symptom relief and maintenance therapy. However, its use requires careful medical supervision due to the risk of dependence, tolerance, and withdrawal symptoms upon abrupt discontinuation. Common side effects may include drowsiness, dizziness, fatigue, and impaired coordination. It is contraindicated in patients with severe respiratory insufficiency, myasthenia gravis, or acute narrow-angle glaucoma. While highly effective when prescribed correctly, Diazepam remains a controlled substance in many jurisdictions because of its potential for misuse and abuse. Ongoing research continues to explore optimized dosing strategies to maximize therapeutic benefits while minimizing adverse outcomes, ensuring it remains a vital tool in modern psychiatry and neurology.
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