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CAS NO:
426-17-5
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ChP,
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Basic Info
CAS Number
426-17-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Dexamethasone is a potent synthetic glucocorticoid belonging to the corticosteroid family, widely recognized for its anti-inflammatory and immunosuppressive properties. Its chemical formula is C22H29FO5, and it is identified by the CAS number 50-02-2. Structurally characterized by a fluorine atom at the C9 position and a methyl group at C16, these modifications significantly enhance its anti-inflammatory potency while minimizing mineralocorticoid activity compared to earlier steroids like hydrocortisone.
Clinically, Dexamethasone serves as a cornerstone in treating a vast array of conditions involving inflammation, allergic reactions, and autoimmune disorders. It is frequently prescribed for severe asthma exacerbations, rheumatoid arthritis, systemic lupus erythematosus, and various dermatological conditions such as severe eczema or psoriasis. Beyond internal medicine, it plays a critical role in oncology, where it helps manage nausea and vomiting associated with chemotherapy and reduces cerebral edema in brain tumor patients. Furthermore, it is utilized in organ transplantation to prevent rejection and in endocrine therapy for congenital adrenal hyperplasia.
The drug exerts its effects by binding to intracellular glucocorticoid receptors, thereby modulating gene transcription to suppress the production of pro-inflammatory cytokines and inhibit immune cell migration. Due to its long half-life and high bioavailability, it can be administered orally, intravenously, intramuscularly, or topically, offering flexibility in clinical settings. However, prolonged use requires careful monitoring due to potential side effects, including hyperglycemia, osteoporosis, weight gain, hypertension, and increased susceptibility to infections. Despite these risks, its efficacy in rapidly controlling life-threatening inflammatory states makes Dexamethasone an indispensable tool in modern pharmacotherapy. It remains a standard component in emergency protocols for anaphylaxis and septic shock, underscoring its versatility across diverse medical disciplines. As a generic medication available globally, it ensures accessibility for patients requiring immediate and effective anti-inflammatory intervention.
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