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CAS NO:
57164-17-7
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Basic Info
CAS Number
57164-17-7
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Desipramine is a tricyclic antidepressant (TCA) widely utilized in the treatment of major depressive disorder. Its chemical identity is defined by the molecular formula C19H23N and a specific CAS registry number, 549-18-8. Structurally, it serves as the active N-demethylated metabolite of imipramine, often exhibiting a more favorable side-effect profile regarding sedation compared to its parent compound. As a potent inhibitor of norepinephrine reuptake, desipramine works primarily by increasing the concentration of norepinephrine in the synaptic cleft, thereby enhancing neurotransmission associated with mood regulation.
Clinically, this medication is indicated for the management of moderate to severe depression, particularly when other treatments have proven ineffective or are contraindicated. While selective serotonin reuptake inhibitors (SSRIs) are frequently prescribed as first-line therapies due to their safety profiles, desipramine remains a valuable option for patients who do not respond adequately to newer agents. Beyond its primary indication, off-label applications include the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and certain types of neuropathic pain. The drug is typically administered orally in tablet form, with dosing adjusted based on individual patient response and tolerability.
Despite its efficacy, desipramine requires careful monitoring due to potential adverse effects. Common side effects include dry mouth, blurred vision, constipation, urinary retention, and drowsiness. More serious risks involve cardiac arrhythmias, orthostatic hypotension, and seizures, necessitating caution in patients with pre-existing heart conditions. Additionally, abrupt discontinuation should be avoided to prevent withdrawal symptoms. Physicians must consider drug interactions, especially with monoamine oxidase inhibitors (MAOIs), which can lead to hypertensive crises. Overall, while desipramine represents a classic pharmacological approach to psychiatric care, its use demands a balanced assessment of therapeutic benefits against potential cardiovascular and anticholinergic risks, ensuring safe and effective long-term management of depressive symptoms.
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