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CAS NO:
201530-78-1
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Basic Info
CAS Number
201530-78-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Deferasirox is a potent oral iron chelating agent primarily utilized in the management of chronic iron overload. This condition frequently arises in patients requiring regular blood transfusions, such as those suffering from beta-thalassemia major or other refractory anemias, as well as individuals with non-transfusion-dependent thalassemia syndromes. The drug functions by binding excess free iron in the body, forming a stable complex that is subsequently excreted through the feces, thereby preventing iron accumulation in vital organs like the heart and liver which could lead to severe toxicity and organ failure.
The molecular formula of Deferasirox is C15H12N4O3S, and it is identified by the CAS registry number 207328-13-2. Structurally, it belongs to the triazole class of compounds, specifically designed with high affinity for ferric iron (Fe3+). Unlike earlier generation chelators such as deferoxamine, which requires subcutaneous or intravenous infusion over extended periods, Deferasirox offers the significant advantage of oral administration. It is typically taken once daily on an empty stomach to ensure optimal absorption and bioavailability. Clinical studies have demonstrated its efficacy in reducing serum ferritin levels and decreasing hepatic iron concentration effectively.
Beyond its therapeutic applications, Deferasirox plays a crucial role in improving the quality of life for patients by eliminating the burden of frequent hospital visits associated with parenteral therapies. However, its use requires careful monitoring due to potential adverse effects, including renal impairment, gastrointestinal disturbances, and skin rashes. Dosage adjustments are often necessary based on individual patient response and iron burden metrics. As a cornerstone therapy in hematology, Deferasirox represents a critical advancement in managing iron overload disorders, offering a convenient and effective solution for long-term treatment strategies while minimizing the risks associated with iron-induced oxidative stress and tissue damage.
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