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Active Pharmaceutical Ingredients

DBCO-acid

Category:

Active Pharmaceutical Ingredients

CAS NO:

1353016-70-2

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Shanghai Haoyuan Chemexpress Co., Ltd.

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Basic Info

CAS Number

1353016-70-2

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Packaging & Delivery

Packaging Specification

Product Description

Standard :In-house Standards

AI Product Description

*The following content is generated by AI and is for reference only.

DBCO-acid, chemically known as Dibenzocyclooctyne-carboxylic acid, is a highly specialized reagent widely utilized in modern chemical biology and bioconjugation applications. Its molecular formula is typically C24H15NO2, though specific derivatives may vary slightly depending on the counterion or functionalization. The compound does not possess a single universal CAS number because it represents a class of molecules where the carboxylic acid moiety can be attached to various DBCO scaffolds; however, common variants often fall under catalog numbers provided by major suppliers like Sigma-Aldrich or Click Chemistry Tools rather than a single public CAS registry entry for the generic term. The primary significance of DBCO-acid lies in its ability to facilitate strain-promoted azide-alkyne cycloaddition (SPAAC), a powerful "click" chemistry reaction that proceeds without the need for toxic copper catalysts. This feature makes it indispensable for labeling biomolecules such as proteins, antibodies, nucleic acids, and lipids within live cells or complex biological environments. The strained alkyne ring in the dibenzocyclooctyne structure provides the necessary thermodynamic drive to react rapidly with organic azides, forming a stable triazole linkage. The carboxylic acid group serves as a versatile handle, allowing researchers to easily couple the DBCO moiety to amine-containing compounds via standard carbodiimide chemistry (e.g., EDC/NHS activation). This enables the synthesis of custom probes for fluorescence imaging, mass spectrometry analysis, and drug delivery systems. In research settings, DBCO-acid is frequently employed to label metabolic sugars, track protein dynamics, or construct antibody-drug conjugates (ADCs) with high specificity. Its biocompatibility ensures minimal interference with cellular processes, making it superior to traditional copper-catalyzed methods for in vivo studies. As the demand for precise molecular targeting grows in pharmaceutical development and diagnostic imaging, DBCO-acid remains a cornerstone reagent for enabling efficient, bioorthogonal modifications. Researchers rely on its stability and predictable reactivity to create sophisticated tools for understanding disease mechanisms and developing novel therapeutics. Consequently, this molecule bridges the gap between synthetic organic chemistry and advanced biological investigation, offering a robust solution for attaching functional groups to delicate biological targets with precision and efficiency.