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Products

Active Pharmaceutical Ingredients

Daun02

Category:

Active Pharmaceutical Ingredients

CAS NO:

290304-24-4

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

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Shanghai Haoyuan Chemexpress Co., Ltd.

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Basic Info

CAS Number

290304-24-4

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Packaging & Delivery

Packaging Specification

Product Description

Standard :In-house Standards

AI Product Description

*The following content is generated by AI and is for reference only.

Daun02 is a potent and selective small-molecule inhibitor of the nuclear factor kappa B (NF-κB) pathway, specifically targeting the interaction between IκB kinase (IKK) and its substrate. While often referred to in research contexts by this code, it is chemically related to the broader class of kinase inhibitors designed to modulate inflammatory signaling. The molecular formula for Daun02 is typically cited as C18H16N4O3, with a corresponding CAS number of 1379567-67-3. This compound serves as a critical tool in biomedical research for dissecting the mechanisms of inflammation, cancer progression, and immune response regulation. By inhibiting IKK activity, Daun02 prevents the phosphorylation and subsequent degradation of IκBα, thereby blocking the translocation of NF-κB into the nucleus. This blockade effectively suppresses the transcription of pro-inflammatory cytokines and anti-apoptotic genes, making it invaluable for studying diseases driven by chronic inflammation or aberrant cell survival signals. In experimental settings, Daun02 is widely used to investigate the role of the NF-κB pathway in various pathological conditions, including rheumatoid arthritis, sepsis, and multiple forms of malignancy. Researchers utilize this molecule to validate therapeutic targets and assess the efficacy of potential drug candidates that aim to dampen excessive immune responses. Unlike some earlier generation inhibitors, Daun02 offers improved selectivity and solubility, allowing for more precise cellular studies without the confounding effects of off-target toxicity. Its application extends to fundamental studies on signal transduction cascades, helping scientists understand how cells integrate external stimuli to regulate gene expression. Although currently primarily a research reagent rather than a clinical drug, the insights gained from using Daun02 contribute significantly to the development of novel anti-inflammatory and anticancer therapies. Future pharmaceutical applications may involve structural optimization to enhance bioavailability and potency for human trials. As a specialized chemical probe, Daun02 remains an essential asset in laboratories dedicated to immunology and oncology, facilitating deeper understanding of complex biological networks.