*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Daptomycin is a cyclic lipopeptide antibiotic produced via fermentation of <strong>Saccharopolyspora rosea</strong>. Its molecular formula is <strong>C66H95CaN17O24</strong> (CAS: 105364-82-1), featuring a calcium-dependent mechanism to disrupt bacterial cell membranes.</p>
<h3>Application</h3>
<ul>
<li><strong>Hospital Infections:</strong> Treatment of complicated skin and soft tissue infections.</li>
<li><strong>Bacteremia:</strong> Management of Staphylococcus aureus bacteremia, including right-sided endocarditis.</li>
<li><strong>VRE:</strong> Alternative therapy for Vancomycin-resistant Enterococcal infections.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in pulmonary infections due to surfactant inactivation. Monitor creatine phosphokinase levels to prevent myopathy. Store lyophilized powder below 25°C in dry conditions; reconstituted solutions must be used immediately or stored at 2–8°C for up to 24 hours.</p>