Daprodustat Biological Activity
Description:Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
In Vitro:GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers.
Density:1.4±0.1 g/cm3
Molecular Formula:C19H27N3O6
Molecular Weight:393.434
Exact Mass:393.189972
PSA:124.09000
LogP:0.86
Index of Refraction:1.580