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Basic Info
CAS Number
N/A
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Cloxacillin is a semi-synthetic penicillin antibiotic belonging to the penicillinase-resistant class, specifically designed to combat infections caused by beta-lactamase-producing Staphylococcus aureus. Its molecular formula is C19H18ClN3O5S, and it is uniquely identified by CAS Registry Number 66-72-4. This compound features a distinctive bulky side chain attached to the 6-aminopenicillanic acid nucleus, which sterically hinders access to the beta-lactamase enzyme, thereby preserving its antibacterial activity in environments where other penicillins would be rapidly degraded.
Primarily utilized in clinical settings, Cloxacillin serves as a critical therapeutic agent for treating skin and soft tissue infections, including cellulitis, abscesses, and wound infections, when these are confirmed or strongly suspected to be caused by methicillin-sensitive Staphylococci. It is also effective against osteomyelitis and septicemia resulting from susceptible staphylococcal strains. Due to its resistance to staphylococcal penicillinase, it remains a first-line choice in many protocols before the widespread emergence of MRSA (Methicillin-Resistant Staphylococcus Aureus). The drug is typically administered orally in capsule or suspension forms for mild to moderate infections, while intravenous or intramuscular routes are reserved for severe systemic infections requiring rapid therapeutic levels.
Pharmacokinetically, Cloxacillin exhibits good oral bioavailability, though food can slightly delay absorption. It distributes well into tissues but does not cross the blood-brain barrier effectively, limiting its utility in meningitis cases. Common side effects include gastrointestinal disturbances such as nausea, vomiting, and diarrhea, alongside potential hypersensitivity reactions ranging from rashes to anaphylaxis in penicillin-allergic individuals. As with all beta-lactams, monitoring for superinfections like candidiasis is essential during prolonged therapy. Despite the rise of resistant bacterial strains globally, Cloxacillin continues to play a vital role in managing susceptible staphylococcal infections, particularly in dermatological and orthopedic applications where rapid control of local infection is paramount. Its stability against specific enzymatic degradation ensures its enduring relevance in antimicrobial stewardship strategies targeting gram-positive cocci.
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