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CAS NO:
17321-77-6
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Basic Info
CAS Number
17321-77-6
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Clomipramine is a tricyclic antidepressant (TCA) primarily utilized in the treatment of obsessive-compulsive disorder (OCD), though it also serves as an effective intervention for major depressive episodes and certain anxiety disorders. With the molecular formula C19H23ClN2, this compound features a distinctive tricyclic structure comprising three fused rings, which facilitates its interaction with various neurotransmitter systems within the central nervous system. Its Chemical Abstracts Service (CAS) registry number is 113-55-7, a unique identifier essential for regulatory compliance, pharmaceutical manufacturing, and scientific research documentation worldwide.
The primary mechanism of action involves the potent inhibition of serotonin reuptake, making it one of the most selective agents in its class for increasing synaptic serotonin levels. While it also affects norepinephrine reuptake to a lesser extent, this serotonergic activity underpins its superior efficacy in managing OCD compared to many other TCAs. Clinically, Clomipramine is often reserved for cases where selective serotonin reuptake inhibitors (SSRIs) have proven ineffective or are not tolerated due to its robust therapeutic profile. It is available in oral tablet forms, typically starting at low doses that are gradually titrated upward to minimize adverse effects while maximizing clinical benefit.
Common side effects stem from its anticholinergic properties and include dry mouth, constipation, blurred vision, urinary retention, and sedation. Patients may also experience weight gain, orthostatic hypotension, or cardiac conduction abnormalities, necessitating careful monitoring during therapy initiation. Despite these challenges, its ability to significantly reduce intrusive thoughts and compulsive behaviors has established it as a gold-standard alternative in psychiatric pharmacotherapy. The drug requires strict adherence to dosing schedules and medical supervision, particularly regarding potential interactions with monoamine oxidase inhibitors (MAOIs) or other serotonergic agents that could precipitate serotonin syndrome. Overall, Clomipramine remains a vital tool in modern psychiatry, offering hope to patients suffering from severe, refractory mood and anxiety conditions when standard treatments fail.
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