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CAS NO:
50-41-9
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ChP,
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Basic Info
CAS Number
50-41-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Clomifene, commonly known as Clomiphene Citrate, is a potent non-steroidal selective estrogen receptor modulator (SERM) widely utilized in reproductive medicine. Its molecular formula is C26H28ClNO and it bears the CAS registry number 50-41-9. First synthesized in the late 1950s, this compound has become a cornerstone therapy for treating female infertility caused by ovulatory dysfunction. The primary mechanism of action involves blocking estrogen receptors in the hypothalamus. By inhibiting the negative feedback loop normally exerted by endogenous estrogen, Clomifene stimulates the release of gonadotropin-releasing hormone (GnRH). This cascade subsequently triggers the anterior pituitary gland to increase the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby promoting follicular development and inducing ovulation in women with conditions such as polycystic ovary syndrome (PCOS).
Beyond its standard gynecological applications, Clomifene is occasionally prescribed off-label for male hypogonadism to stimulate endogenous testosterone production and improve sperm parameters, although evidence varies regarding its efficacy in this demographic. It is typically administered orally in tablet form over a specific cycle duration, usually five days starting from the fifth day of menstruation. While generally well-tolerated, common side effects include hot flashes, mood swings, abdominal discomfort, and visual disturbances, which necessitate careful patient monitoring. Serious risks may include ovarian hyperstimulation syndrome or multiple gestations if not managed correctly. Despite the advent of newer fertility agents like letrozole, Clomifene remains a first-line treatment globally due to its established safety profile, cost-effectiveness, and extensive clinical history. Its unique pharmacological properties make it an indispensable tool in assisted reproductive technologies, offering hope to countless individuals struggling with conception challenges related to anovulation. Continuous research ensures its optimal usage protocols are refined for better patient outcomes.
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