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<h3>Overview</h3>
<p>Clofarabine is a second-generation purine nucleoside analog synthesized via <strong>enzymatic phosphorylation</strong>. Its molecular formula is C10H12ClN5O4P, and the CAS number is 168719-66-2.</p>
<h3>Application</h3>
<ul>
<li>Oncology: Treatment of relapsed or refractory acute lymphoblastic leukemia (ALL) in pediatric patients.</li>
<li>Hematology: Investigational use in myelodysplastic syndromes (MDS) and chronic myeloid leukemia (CML).</li>
<li>Research: Tool compound for studying DNA synthesis inhibition mechanisms in vitro.</li>
</ul>
<h3>Precautions</h3>
<p>Requires strict oncology supervision due to severe toxicity. Store at -20°C in sealed containers away from moisture. Avoid direct skin contact during handling.</p>