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CAS NO:
18323-44-9
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ChP,
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Basic Info
CAS Number
18323-44-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Clindamycin is a widely utilized semi-synthetic antibiotic derived from lincomycin, belonging to the lincosamide class of antimicrobial agents. Its chemical identity is defined by the molecular formula C₁₈H₃₃ClN₂O₅S and the CAS registry number 18323-44-9. Structurally, it features a pyrrolidine ring and a thioether linkage, which are critical for its biological activity against a broad spectrum of bacteria. The drug functions primarily by inhibiting bacterial protein synthesis; it binds reversibly to the 50S subunit of the bacterial ribosome, thereby blocking peptide bond formation and preventing the elongation of the peptide chain. This mechanism renders Clindamycin highly effective against Gram-positive aerobic bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus species, as well as anaerobic organisms such as Bacteroides and Clostridium perfringens.
Clinically, Clindamycin serves as a versatile therapeutic option for treating various infections where other antibiotics may be ineffective or contraindicated due to patient allergies. It is frequently prescribed for serious skin and soft tissue infections, osteomyelitis, intra-abdominal abscesses, and pelvic inflammatory disease. Furthermore, its ability to penetrate bone tissue makes it a preferred choice for managing bone infections. In dentistry, it is often used to treat periodontal diseases and oral abscesses. Beyond human medicine, Clindamycin finds applications in veterinary practice for treating similar infections in animals. It is available in multiple formulations, including capsules, topical gels, lotions, and intravenous solutions, allowing for flexible administration routes depending on the severity and location of the infection. While generally well-tolerated, clinicians must monitor patients for potential adverse effects, most notably pseudomembranous colitis caused by Clostridioides difficile overgrowth. Despite these risks, Clindamycin remains a cornerstone in modern antimicrobial therapy, particularly for resistant strains and anaerobic infections, ensuring its continued relevance in global healthcare protocols.
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