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CAS NO:
4744-51-8
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Basic Info
CAS Number
4744-51-8
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Clavulanate Potassium is a widely utilized pharmaceutical compound primarily employed as a beta-lactamase inhibitor to enhance the efficacy of certain antibiotics. Chemically known as potassium (2R,3S)-5-oxo-2-(4-oxo-1H-pyrrol-3-yl)butanoate, its molecular formula is C8H8KNO5 and it carries the CAS Registry Number 61177-45-5. This substance belongs to the class of clavams, which are structurally related to penicillins but possess a unique oxazolidine ring fused to a pyrrolone system. The primary mechanism of action involves irreversible binding to beta-lactamase enzymes produced by resistant bacteria. By inhibiting these enzymes, Clavulanate Potassium prevents the hydrolysis of beta-lactam antibiotics such as amoxicillin or ticarcillin, thereby restoring their antibacterial activity against organisms that would otherwise be resistant.
Clinically, this agent is almost exclusively administered in fixed-dose combination formulations rather than as a standalone drug due to its weak intrinsic antibacterial properties. The most common commercial preparations include Amoxicillin/Clavulanate Potassium, which is a first-line treatment for a broad spectrum of bacterial infections. These infections range from respiratory tract ailments like acute bronchitis and pneumonia to skin and soft tissue infections, otitis media, sinusitis, and urinary tract infections. It is particularly effective against beta-lactamase-producing strains of *Haemophilus influenzae*, *Moraxella catarrhalis*, *Staphylococcus aureus*, and various anaerobic bacteria found in the oral cavity and gastrointestinal tract.
The pharmacokinetic profile of Clavulanate Potassium shows good absorption after oral administration, with peak plasma concentrations reached within one hour. It distributes well into various body tissues and fluids, including bile, synovial fluid, and lung tissue. Common side effects may include gastrointestinal disturbances such as diarrhea, nausea, and vomiting, while rare hypersensitivity reactions can occur in patients with penicillin allergies. As a critical component in modern antimicrobial stewardship, Clavulanate Potassium plays an indispensable role in combating antibiotic resistance, ensuring that standard beta-lactam antibiotics remain effective therapeutic options for treating complex bacterial infections globally. Its continued availability is vital for maintaining high standards of infectious disease management in clinical settings worldwide.
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