Category:
Finished Dosage
CAS NO:
51481-61-9
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Basic Info
Is Manufacturer
YES
Samples Provided
NO
Packaging & Delivery
Packaging Specification
10 ampoules/tray/box
Product Description
1.Product name: Cimetidine Injection
2.Specification: 200mg/2ml
3.Package: 10 ampoules/tray/box
4.Shelf life: 36 months
5.Registration documents are available.
If you are interested in our products,please feel free to contact us
AI Product Description
*The following content is generated by AI and is for reference only.
Cimetidine Injection is a potent intravenous medication belonging to the class of histamine H2-receptor antagonists. Primarily indicated for the treatment and prevention of active duodenal ulcers, gastric ulcers, and pathological hypersecretory conditions such as Zollinger-Ellison syndrome, it functions by competitively blocking histamine at the H2 receptors located on parietal cells in the stomach lining. This blockade effectively inhibits both basal and stimulated gastric acid secretion, creating an environment conducive to ulcer healing and symptom relief. In clinical settings, this injectable formulation is particularly valuable for patients who are unable to tolerate oral medications due to nausea, vomiting, or critical illness requiring rapid acid suppression, such as those with stress-related mucosal damage in intensive care units.
The administration of Cimetidine Injection requires careful medical supervision. It is typically administered via slow intravenous injection or continuous infusion, with dosage adjusted based on the severity of the condition and patient response. A critical safety consideration involves its potential for significant drug-drug interactions. As Cimetidine is a known inhibitor of several cytochrome P450 enzymes, including CYP1A2, CYP2C9, and CYP3A4, it can alter the metabolism of concurrent medications such as warfarin, phenytoin, and certain benzodiazepines, potentially leading to toxic levels of these drugs. Consequently, dose adjustments or close monitoring of plasma concentrations are often necessary when co-administered.
Special caution is advised for elderly patients, individuals with hepatic or renal impairment, as reduced clearance may necessitate dosage reduction to prevent accumulation and adverse effects like confusion or gynecomastia. While generally well-tolerated, common side effects may include headache, dizziness, diarrhea, or transient elevations in liver enzymes. Patients should be monitored for signs of blood dyscrasias, though rare, and immediate discontinuation is warranted if severe hypersensitivity reactions occur. Overall, while Cimetidine Injection remains a cornerstone therapy for acute acid-related disorders, its use demands rigorous assessment of patient history and concomitant therapies to ensure optimal therapeutic outcomes and safety.
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