*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Cilastatin Sodium is a renal dehydropeptidase-I inhibitor used to prevent the degradation of beta-lactam antibiotics. It is synthesized via <strong>chemical synthesis</strong> with the molecular formula <strong>C<sub>10</sub>H<sub>16</sub>N<sub>2</sub>O<sub>4</sub>S·Na</strong> and CAS No. 57894-90-3.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical Manufacturing:</strong> Combined with imipenem in fixed-dose injectable formulations for severe bacterial infections.</li>
<li><strong>Antibiotic Therapy:</strong> Extends the half-life of carbapenems by inhibiting renal metabolism.</li>
<li><strong>Research & Development:</strong> Used as a reference standard in bioequivalence studies.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly avoid use in patients with known hypersensitivity to carbapenems. Store under <strong>controlled temperature</strong> (2-8°C) in dry conditions to maintain stability. Handle with appropriate PPE to prevent inhalation or skin contact.</p>