Product Description
Reference Standards &Impurity
AI Product Description
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Chlortetracycline, chemically known as 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, is a broad-spectrum tetracycline antibiotic. Its molecular formula is C22H23ClN2O8, and it carries the CAS registry number 64-75-5. First isolated from *Streptomyces aureofaciens* in 1948, this compound was historically significant as one of the earliest tetracyclines introduced for clinical use, though its application has diminished in human medicine due to the emergence of more effective and less toxic alternatives.
Primarily utilized today in veterinary medicine and agriculture, Chlortetracycline serves as a critical tool for treating and preventing bacterial infections in livestock, poultry, and aquaculture species. It effectively targets a wide range of Gram-positive and Gram-negative bacteria by binding reversibly to the 30S ribosomal subunit, thereby inhibiting protein synthesis essential for bacterial growth. Common applications include managing respiratory diseases in swine, treating enteric infections in cattle, and controlling outbreaks in fish farms. The drug is frequently administered via feed or water additives, often in combination with other nutrients to promote growth efficiency in healthy animals under specific regulatory frameworks.
Despite its utility, the global usage of Chlortetracycline faces increasing scrutiny regarding antimicrobial resistance (AMR). The overuse of tetracyclines in animal husbandry contributes significantly to the proliferation of resistant bacterial strains, posing potential risks to public health through the food chain. Consequently, many regions have implemented strict regulations limiting its prophylactic use, mandating that it be reserved for therapeutic purposes under veterinary supervision. Additionally, withdrawal periods are strictly enforced before meat or milk products enter the market to ensure residue levels remain below safety thresholds. While newer generations of antibiotics have largely replaced it in human therapy, Chlortetracycline remains an economically vital component in sustainable animal production systems when managed responsibly within modern biosecurity protocols.