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<h3>Overview</h3>
<p><strong>Chlortalidone</strong> is a thiazide-like diuretic used primarily in hypertension management. Synthesized via chlorosulfonation and cyclization, its molecular formula is <strong>C14H11ClN2O5S</strong> with CAS No. <strong>68-45-9</strong>.</p>
<h3>Application</h3>
<ul>
<li>Hypertension treatment as monotherapy or combination therapy.</li>
<li>Edema management in congestive heart failure and renal disorders.</li>
<li>Pharmaceutical bulk manufacturing for generic tablet formulations.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in severe renal impairment and anuria. Store in cool, dry conditions away from light. Personnel must use respiratory protection during handling to avoid inhalation risks.</p>