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Preclinical Research Services
CAS NO:
69-09-0
Standard:
ChP,
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Basic Info
CAS Number
69-09-0
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Chlorpromazine, widely recognized by its generic name and formerly known as Thorazine, is a cornerstone medication in the field of psychopharmacology. Classified chemically as a phenothiazine derivative, its molecular formula is C17H19ClN2S, and it is uniquely identified by the CAS registry number 50-53-3. This compound represents the first antipsychotic drug developed for clinical use, marking a revolutionary shift in the treatment of severe mental disorders during the mid-20th century. Its primary mechanism of action involves the antagonism of dopamine D2 receptors within the central nervous system, specifically in the mesolimbic pathway, which effectively reduces psychotic symptoms such as hallucinations, delusions, and disordered thinking associated with schizophrenia and other acute psychotic states.
Beyond its psychiatric applications, Chlorpromazine possesses versatile pharmacological properties that extend to various non-psychiatric conditions. Due to its potent antiemetic effects mediated through the blockade of dopamine receptors in the chemoreceptor trigger zone, it is frequently utilized to manage severe nausea and vomiting, particularly those induced by chemotherapy, radiation therapy, or surgical procedures. Furthermore, its sedative and muscle-relaxant qualities make it useful in controlling intractable hiccups, managing preoperative anxiety, and providing adjunctive therapy for tetanus or alcohol withdrawal syndromes. The drug also exhibits significant alpha-adrenergic blocking activity, leading to vasodilation and potential hypotension, which must be carefully monitored during administration.
While highly effective, Chlorpromazine usage requires vigilance regarding side effects, including extrapyramidal symptoms like tremors and rigidity, anticholinergic effects such as dry mouth and blurred vision, and metabolic disturbances. Long-term use may occasionally lead to tardive dyskinesia or photosensitivity reactions. Despite the advent of newer atypical antipsychotics with improved safety profiles, Chlorpromazine remains a vital therapeutic agent globally due to its efficacy, low cost, and established safety record when used under strict medical supervision. It continues to serve as a fundamental reference point in understanding neuroleptic mechanisms and treating complex neuropsychiatric presentations worldwide.
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