Category:
Cephalosporins
CAS NO:
38821-53-3
Standard:
ChP,USP,
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Basic Info
CAS Number
38821-53-3
Pharmacopoeia
ChP,USP
Grade
Injection Grade
Is Manufacturer
YES
Samples Provided
YES
Product Description
white or almost white crystalline powder
AI Product Description
*The following content is generated by AI and is for reference only.
Cephradine Sterile, commonly known as Cephalothin or simply Cephradine, is a first-generation cephalosporin antibiotic available in sterile powder form for parenteral administration. Its chemical identity is defined by the molecular formula C16H19N3O5S and the CAS Registry Number 57-20-7. This beta-lactam compound functions by inhibiting bacterial cell wall synthesis, specifically binding to penicillin-binding proteins (PBPs) and disrupting peptidoglycan cross-linking, which ultimately leads to cell lysis and death. It exhibits broad-spectrum activity against both Gram-positive and select Gram-negative organisms, making it particularly effective against Staphylococcus aureus (including penicillinase-producing strains), Streptococcus species, Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
The sterile powder formulation is designed for reconstitution with appropriate solvents such as sterile water for injection or normal saline immediately prior to use. Once prepared, the solution is typically administered via intramuscular injection or slow intravenous infusion. This route ensures rapid therapeutic blood concentrations, which is critical for treating acute infections. Clinically, Cephradine Sterile is indicated for the management of respiratory tract infections, urinary tract infections, skin and soft tissue infections, bone and joint infections, and otitis media. It serves as a vital alternative for patients allergic to penicillin, provided there is no history of severe hypersensitivity reactions to cephalosporins.
Despite its efficacy, the drug carries potential risks including gastrointestinal disturbances, hypersensitivity reactions ranging from rash to anaphylaxis, and transient elevations in liver enzymes. Renal function must be monitored during prolonged therapy, as cephalosporins are primarily excreted unchanged by the kidneys. The sterile nature of the powder is paramount to prevent contamination, ensuring patient safety during administration in hospital settings. While newer generations of antibiotics have emerged, Cephradine remains a cost-effective and reliable option for specific bacterial infections, particularly in resource-limited environments or when targeted therapy against susceptible Gram-positive pathogens is required. Proper storage in a cool, dry place away from light preserves its stability until the expiration date.
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