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CAS NO:
80210-62-4
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ChP,
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Basic Info
CAS Number
80210-62-4
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Cefpodoxime Proxetil is a widely utilized third-generation cephalosporin antibiotic, serving as the prodrug of cefpodoxime. Its chemical identity is defined by the molecular formula C20H23N5O8S3 and the CAS Registry Number 87409-13-6. Structurally, it features a beta-lactam ring essential for its antibacterial activity, combined with specific side chains that enhance its stability against bacterial beta-lactamases. As a prodrug, cefpodoxime proxetil itself possesses no significant antimicrobial properties; however, upon oral administration, it undergoes rapid hydrolysis in the gastrointestinal tract to release the active moiety, cefpodoxime, which exerts the therapeutic effect.
The primary clinical utility of this compound lies in its broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria. It is particularly effective against pathogens such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and various strains of Escherichia coli and Klebsiella species. Due to its excellent oral bioavailability and tissue penetration, it is frequently prescribed for treating respiratory tract infections, including acute exacerbations of chronic bronchitis, community-acquired pneumonia, and otitis media. Furthermore, it demonstrates efficacy in managing urinary tract infections, skin and soft tissue infections, and uncomplicated gonorrhea.
A key advantage of cefpodoxime proxetil over earlier generation cephalosporins is its enhanced resistance to degradation by beta-lactamase enzymes produced by resistant organisms. This characteristic allows it to remain effective in cases where penicillins or first-generation cephalosporins might fail. The drug is typically administered orally in tablet or suspension forms, offering convenience for outpatient management and pediatric patients. While generally well-tolerated, common adverse effects may include gastrointestinal disturbances such as diarrhea, nausea, and abdominal pain, as well as potential hypersensitivity reactions in patients with known penicillin allergies. Overall, cefpodoxime proxetil represents a critical tool in modern antimicrobial therapy, balancing potent bactericidal activity with a favorable safety profile for treating diverse infectious diseases.
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