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Basic Info
CAS Number
N/A
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Cefpiramide is a broad-spectrum, third-generation cephalosporin antibiotic characterized by its unique chemical structure and potent antimicrobial activity. With the Chemical Abstracts Service (CAS) number 67980-34-5, this compound possesses the molecular formula C22H24N6O8S3. Its structural framework includes a beta-lactam ring fused to a dihydrothiazine ring, which is essential for inhibiting bacterial cell wall synthesis. The molecule also features a distinctive pyridinium side chain that enhances its stability against various beta-lactamases produced by resistant bacteria.
The primary clinical application of Cefpiramide lies in the treatment of severe infections caused by Gram-negative organisms, including Escherichia coli, Klebsiella pneumoniae, Proteus species, and Pseudomonas aeruginosa. It demonstrates exceptional efficacy against urinary tract infections, respiratory tract infections, septicemia, and complicated intra-abdominal infections. Due to its high protein binding capacity and prolonged half-life, it allows for less frequent dosing compared to earlier generation cephalosporins, improving patient compliance. Furthermore, Cefpiramide exhibits good tissue penetration, reaching therapeutic concentrations in the lungs, kidneys, and liver, making it suitable for treating deep-seated infections.
Mechanistically, Cefpiramide acts as a bactericidal agent by binding to penicillin-binding proteins (PBPs) located on the inner membrane of susceptible bacteria. This binding disrupts the cross-linking of peptidoglycan layers, leading to cell wall instability and subsequent bacterial lysis. While generally well-tolerated, potential adverse effects may include gastrointestinal disturbances, rash, or transient elevations in liver enzymes. Allergic reactions, particularly in patients with known penicillin or cephalosporin hypersensitivity, require careful monitoring. As an injectable formulation, it is typically administered intravenously or intramuscularly under strict medical supervision. Although newer antibiotics have emerged, Cefpiramide remains a valuable therapeutic option in specific clinical scenarios involving multidrug-resistant pathogens, contributing significantly to modern infectious disease management protocols worldwide.
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