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CAS NO:
138514-32-6
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Basic Info
CAS Number
138514-32-6
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Cefditoren Pivoxil is a third-generation oral cephalosporin antibiotic widely utilized in clinical settings for the treatment of various bacterial infections. Chemically identified by the CAS number 103984-76-3, its molecular formula is C24H25N5O7S2. This compound serves as a prodrug of cefditoren, designed to enhance oral bioavailability through improved absorption in the gastrointestinal tract. Once administered, esterases in the intestinal wall and blood rapidly hydrolyze the pivoxil moiety, releasing the active parent drug, cefditoren, which exerts potent bactericidal effects.
The primary mechanism of action involves the inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), specifically targeting PBPs in susceptible Gram-positive and Gram-negative organisms. Cefditoren Pivoxil demonstrates broad-spectrum activity against common respiratory pathogens, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, making it highly effective for acute exacerbations of chronic bronchitis, community-acquired pneumonia, and pharyngitis/tonsillitis caused by Streptococcus pyogenes. It also shows efficacy against skin and soft tissue infections due to its coverage of Staphylococcus aureus, provided the strain is methicillin-sensitive.
A key advantage of this agent is its stability against many beta-lactamases produced by resistant bacteria, offering a valuable alternative where other antibiotics might fail. Unlike some earlier generations, it maintains good activity against beta-lactamase-producing strains while preserving a favorable safety profile with minimal disruption to normal gut flora compared to broader-spectrum alternatives. Common side effects are generally mild and may include diarrhea, nausea, or headache, though hypersensitivity reactions can occur in patients with penicillin allergies. Dosage regimens typically involve twice-daily administration with food to maximize absorption. As an essential component of antimicrobial stewardship programs, Cefditoren Pivoxil remains a critical tool for managing uncomplicated respiratory and dermatological infections globally, balancing efficacy with a manageable adverse event profile for outpatient therapy.
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