
Carbetocin is a synthetic agonist, long-acting nine-peptide analogue of oxytocin. The clinical and pharmacological properties of carbetocin are similar to those of naturally occurring oxytocin. It is suitable for elective epidural or lumbar anesthesia after caesarean section to prevent uterine contraction weakness and postpartum hemorrhage.Like oxytocin, carpetin binds to the oxytocin receptors in the smooth muscle of the uterus, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tension on top of the original contractions.When 100 micrograms of carbetocin was administered intravenously in a single dose immediately after epidural or lumbar anesthesia following caesarean section, carbetocin was significantly superior to placebo in preventing uterine hypotonia and reducing postpartum bleeding.
Specification: 1ml:100ug