Category:
Cardiovascular System Drugs
CAS NO:
145040-37-5
Standard:
USP,BP,
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Basic Info
CAS Number
145040-37-5
Pharmacopoeia
USP,BP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Samples Provided
NO
Product Description
GMP
AI Product Description
*The following content is generated by AI and is for reference only.
Candesartan cilexetil is a widely prescribed prodrug utilized in the management of hypertension and heart failure. Chemically, it serves as an ester prodrug of candesartan, which is a potent angiotensin II receptor blocker (ARB). The molecular formula for Candesartan cilexetil is C34H34N6O6, reflecting its complex organic structure designed to enhance oral bioavailability. Its unique Chemical Abstracts Service (CAS) registry number is 138709-82-9. Upon oral administration, the drug undergoes rapid hydrolysis in the intestinal wall and liver to release the active moiety, candesartan. This active metabolite selectively blocks the binding of angiotensin II to the AT1 receptors found in various tissues, including vascular smooth muscle and the adrenal glands. By inhibiting this critical pathway, Candesartan cilexetil prevents vasoconstriction and reduces aldosterone secretion, effectively lowering blood pressure without triggering the cough reflex often associated with ACE inhibitors.
The therapeutic utility of this compound extends beyond simple blood pressure control. It is indicated for the treatment of essential hypertension in adults and children, helping to reduce the risk of cardiovascular events such as stroke and myocardial infarction. Furthermore, it plays a significant role in managing chronic heart failure, where it improves cardiac function and reduces hospitalization rates by decreasing afterload and preventing adverse cardiac remodeling. The drug is generally well-tolerated, with a favorable safety profile compared to other antihypertensive agents. Common side effects are mild and may include dizziness or headache, though serious adverse reactions are rare. Due to its long half-life and once-daily dosing regimen, it offers excellent patient compliance. Clinical studies have consistently demonstrated its efficacy in achieving target blood pressure levels across diverse patient populations, making it a cornerstone therapy in modern cardiovascular medicine. Its specific chemical design ensures stable pharmacokinetics, allowing for consistent therapeutic outcomes regardless of food intake.
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