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Other Specialized Reagents

Bisoprolol fumarate

Category:

Other Specialized Reagents

CAS NO:

104344-23-2

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Jianfeng Chemical Co., Ltd.

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Basic Info

CAS Number

104344-23-2

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

Bisoprolol fumarate Chemical Properties

Melting point	100°C
storage temp.	2-8°C
solubility	DMSO: >20 mg/mL
form	solid
color	white
Merck	14,1295
InChIKey	RZPZLFIUFMNCLY-WLHGVMLRSA-N
CAS DataBase Reference	104344-23-2(CAS DataBase Reference)

AI Product Description

*The following content is generated by AI and is for reference only.

Bisoprolol fumarate is a widely prescribed cardiovascular medication belonging to the class of selective beta-1 adrenergic receptor blockers. Chemically, it is identified by the CAS number 95730-42-6 and possesses the molecular formula C₁₈H₃₂NO₄F. As a second-generation beta-blocker, it exhibits high selectivity for cardiac beta-1 receptors, which allows it to effectively reduce heart rate and myocardial contractility while minimizing adverse effects on bronchial smooth muscle compared to non-selective agents. The fumarate salt form enhances its solubility and stability, facilitating efficient oral absorption in clinical settings. The primary therapeutic indications for bisoprolol fumarate include the management of hypertension and chronic stable angina pectoris. By blocking sympathetic stimulation on the heart, it lowers blood pressure and reduces the workload on the myocardium, thereby improving oxygen supply-demand balance in patients with coronary artery disease. Furthermore, it plays a crucial role in the long-term treatment of heart failure with reduced ejection fraction, where it has been proven to decrease mortality rates and hospitalization frequencies when used as part of a comprehensive therapy regimen including ACE inhibitors and diuretics. Its pharmacokinetic profile features linear kinetics and a long half-life of approximately ten to twelve hours, supporting once-daily dosing schedules that significantly improve patient compliance. Common side effects may include fatigue, bradycardia, dizziness, and cold extremities, though these are generally well-tolerated due to its cardioselectivity. Contraindications typically involve severe bradycardia, cardiogenic shock, or decompensated heart failure. Bisoprolol fumarate remains a cornerstone in modern cardiology, offering a favorable safety profile and robust efficacy for managing various hemodynamic disorders. Its widespread availability and established clinical track record make it a standard choice for physicians worldwide aiming to control blood pressure and protect cardiac function in diverse patient populations.