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Active Pharmaceutical Ingredients

Bis-PEG2-NHS ester

Category:

Active Pharmaceutical Ingredients

CAS NO:

65869-63-8

Standard:

In-house Standards,

Price Range:

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Basic Info

CAS Number

65869-63-8

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Samples Provided

Packaging & Delivery

Packaging Specification

Product Description

Standard :In-house Standards

AI Product Description

*The following content is generated by AI and is for reference only.

Bis-PEG2-NHS ester is a versatile heterobifunctional crosslinking reagent widely utilized in biochemical research and biopharmaceutical development. Its molecular formula is C17H30N2O9, corresponding to a molecular weight of approximately 394.43 g/mol. The compound features two reactive NHS (N-hydroxysuccinimide) ester groups positioned at opposite ends of a short, hydrophilic polyethylene glycol (PEG) spacer containing two ethylene oxide units. This unique architecture allows for the efficient conjugation of primary amines on proteins, peptides, or antibodies without requiring a separate amine-reactive partner, making it ideal for creating homodimers or modifying biomolecules with PEG chains to enhance solubility and reduce immunogenicity. The NHS esters readily react with primary amines under mild physiological conditions to form stable amide bonds, releasing N-hydroxysuccinimide as a byproduct. Because both ends possess identical reactivity, this reagent facilitates the formation of symmetrical dimers when reacting with two separate amine-containing molecules, or it can be used to attach a single PEG chain to a protein if one end reacts first followed by quenching. The short PEG2 linker provides flexibility while maintaining a compact profile, which is crucial for preserving the biological activity and steric accessibility of the conjugated target. Unlike longer PEG spacers that might introduce significant distance between functional domains, Bis-PEG2 offers a minimal yet effective separation. This reagent is extensively employed in antibody-drug conjugate (ADC) synthesis, protein labeling, bioconjugation studies, and the preparation of immobilized ligands for chromatography. Researchers utilize it to improve the pharmacokinetic properties of therapeutic proteins or to create defined oligomeric structures for structural biology applications. Proper handling requires storage at low temperatures in anhydrous organic solvents like DMSO or DMF to prevent premature hydrolysis of the NHS esters. Upon exposure to aqueous buffers, the reaction proceeds rapidly, typically within minutes to hours, depending on pH and concentration. Overall, Bis-PEG2-NHS ester remains a fundamental tool for precise molecular engineering in life sciences, enabling the creation of complex bioconjugates with high efficiency and specificity.

Bis-​PEG2-​NHS ester

Basic Info

Product Description

Bis-PEG2-NHS ester