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CAS NO:
472-15-1
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Basic Info
CAS Number
472-15-1
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Betulinic acid is a naturally occurring triterpenoid compound primarily isolated from the bark of white birch trees (Betula pendula) and other plant species such as Syzygium cumini. Its molecular formula is C30H48O3, and it is uniquely identified by the CAS registry number 472-15-1. Structurally characterized by a pentacyclic lupane skeleton, this bioactive molecule has garnered significant attention in pharmaceutical research due to its potent biological properties, particularly its selective cytotoxicity against malignant cells.
The primary application of betulinic acid lies in oncology, where it has demonstrated remarkable efficacy in inducing apoptosis in various cancer cell lines, including melanoma, breast, lung, and prostate cancers. A distinct advantage of this compound is its ability to target tumor cells while exhibiting minimal toxicity toward normal healthy cells, a feature that addresses a major limitation of conventional chemotherapy agents. Mechanistically, it triggers mitochondrial-mediated apoptosis by disrupting membrane potential and activating caspase pathways. Beyond its anti-cancer potential, betulinic acid possesses notable antiviral activity, showing promise in inhibiting HIV replication by interfering with viral maturation processes. Additionally, research indicates its utility as an anti-inflammatory and neuroprotective agent, suggesting broader therapeutic applications in treating chronic inflammatory conditions and neurodegenerative disorders.
Despite its promising profile, the clinical translation of betulinic acid faces challenges related to poor water solubility and rapid metabolic clearance. To overcome these hurdles, scientists are actively developing novel derivatives and nano-formulations designed to enhance bioavailability and target specificity. As a result, betulinic acid remains a cornerstone in the development of next-generation anticancer therapeutics and serves as a vital scaffold for medicinal chemistry innovation. Ongoing preclinical and clinical studies continue to explore its full potential, aiming to transform this natural product into a viable treatment option for life-threatening diseases. Its unique combination of selectivity and potency ensures its continued relevance in modern drug discovery pipelines.
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