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CAS NO:
378-44-9
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ChP,
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Basic Info
CAS Number
378-44-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Betamethasone Valerate is a potent synthetic glucocorticoid widely utilized in dermatological and ophthalmic medicine for its powerful anti-inflammatory, antipruritic, and vasoconstrictive properties. Chemically, it belongs to the class of fluorinated corticosteroids, designed to enhance potency while minimizing mineralocorticoid activity compared to earlier generations. Its molecular formula is C27H37FO6, reflecting a complex steroid backbone with specific hydroxyl and acetoxy substitutions that optimize receptor binding affinity. The substance is uniquely identified by the CAS Registry Number 58-14-0, ensuring precise tracking across pharmaceutical databases and regulatory filings globally.
Clinically, Betamethasone Valerate is primarily indicated for the treatment of various inflammatory skin conditions, including eczema, psoriasis, contact dermatitis, and lichen planus. It is available in multiple formulations such as creams, ointments, lotions, and solutions, allowing clinicians to tailor therapy based on the severity of the condition and the anatomical site involved. The drug works by suppressing the release of inflammatory mediators and inhibiting the migration of leukocytes to the affected area, thereby reducing redness, swelling, and itching. In ophthalmology, it is sometimes employed to manage inflammation associated with allergic conjunctivitis or post-surgical recovery, though systemic absorption remains a critical consideration.
Due to its high potency, this medication requires careful application under medical supervision to avoid adverse effects such as skin atrophy, telangiectasia, or hypothalamic-pituitary-adrenal axis suppression, particularly when used over large surface areas or for prolonged periods. Contraindications include untreated bacterial, fungal, or viral skin infections, as well as hypersensitivity to any component of the formulation. While highly effective, long-term use necessitates monitoring for potential side effects, especially in pediatric patients or those with compromised skin barriers. Overall, Betamethasone Valerate represents a cornerstone therapy in modern dermatology, offering significant relief for chronic inflammatory disorders when prescribed responsibly within established safety guidelines.
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