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Preclinical Research Services
CAS NO:
13504-15-9
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Basic Info
CAS Number
13504-15-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Betamethasone is a potent synthetic glucocorticoid widely utilized in modern medicine for its powerful anti-inflammatory, immunosuppressive, and antipruritic properties. Chemically, it belongs to the corticosteroid class and shares structural similarities with endogenous cortisol but exhibits significantly higher potency and longer duration of action. Its molecular formula is C22H29FO5, and it is uniquely identified by the CAS Registry Number 378-44-9. This compound acts primarily by binding to intracellular glucocorticoid receptors, thereby modulating gene expression to inhibit the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.
Clinically, Betamethasone serves diverse therapeutic roles across multiple medical specialties. In dermatology, it is a cornerstone treatment for various skin conditions including eczema, psoriasis, allergic contact dermatitis, and severe insect bites, often formulated into creams, ointments, or lotions to reduce redness, swelling, and itching. Systemic administration via oral tablets or injectable solutions is critical for managing acute exacerbations of asthma, rheumatoid arthritis, lupus, and other autoimmune disorders where rapid suppression of immune response is necessary. Furthermore, it plays a vital role in obstetrics; when administered to pregnant women at risk of preterm delivery, betamethasone accelerates fetal lung maturity, significantly reducing the incidence of respiratory distress syndrome and neonatal mortality.
The drug is available in several salt forms, most commonly betamethasone sodium phosphate and betamethasone acetate, which allow for tailored pharmacokinetic profiles ranging from rapid onset to prolonged release. While highly effective, long-term use requires careful monitoring due to potential side effects such as adrenal suppression, osteoporosis, hyperglycemia, and increased susceptibility to infection. Despite these risks, its versatility and efficacy make Betamethasone an indispensable agent in both acute emergency care and chronic disease management worldwide.
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