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Basic Info
Is Manufacturer
No
Samples Provided
NO
Packaging & Delivery
Packaging Specification
25kg drum
Product Description
Because the side effects of Azithromycin are less than Cephalosporins, now Azithromycin is the most commonly used antibiotics for bacterial infection-related diseases in our hospital clinic. This drug is a second generation semi-synthetic derivative of macrolide, whose structure is different from Erythromycin. It inserted a methyl-substituted nitrogen in 9a site of Erythromycin lactone ring, generating a 15-membered ring macrolide.
AI Product Description
*The following content is generated by AI and is for reference only.
Azithromycin is a widely prescribed macrolide antibiotic belonging to the azalide subclass, characterized by a modified erythromycin structure featuring a nitrogen atom within its macrocyclic ring. Its molecular formula is C38H72N2O12, and it carries the CAS Registry Number 83905-01-5. This compound acts primarily by inhibiting bacterial protein synthesis; it binds reversibly to the 50S subunit of the bacterial ribosome, thereby blocking the translocation step of peptide chain elongation. Unlike earlier macrolides, azithromycin exhibits a unique pharmacokinetic profile with an exceptionally long half-life, allowing for shorter treatment durations and once-daily dosing regimens. It demonstrates excellent tissue penetration, accumulating in high concentrations within phagocytes and tissues such as the lungs, prostate, and tonsils, far exceeding serum levels.
Clinically, azithromycin is a first-line therapy for a broad spectrum of respiratory tract infections, including community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, and sinusitis. It is also highly effective against skin and soft tissue infections caused by susceptible strains of Staphylococcus aureus and Streptococcus pyogenes. Furthermore, it serves as a critical alternative for treating sexually transmitted infections like chlamydia and gonorrhea, particularly when penicillin resistance is suspected or patient compliance is a concern. The drug is generally well-tolerated, though common side effects may include gastrointestinal disturbances such as nausea, diarrhea, and abdominal pain. Less frequently, it can cause QT interval prolongation, necessitating caution in patients with pre-existing cardiac conditions. Due to its efficacy, convenient dosing schedule, and favorable safety profile, azithromycin remains a cornerstone in modern antimicrobial therapy globally, playing a vital role in managing both common and complex bacterial infections across diverse patient populations.
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