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Basic Info
CAS Number
N/A
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Azasetron is a potent, selective serotonin 5-HT3 receptor antagonist developed primarily for the management of chemotherapy-induced nausea and vomiting (CINV). First synthesized in Japan by Takeda Pharmaceutical Company, this compound has gained significant clinical traction as an effective antiemetic agent. Its molecular formula is C20H21ClN4O2S, and it is universally recognized by the CAS number 169874-47-7. Structurally, Azasetron features a complex arrangement containing a chlorophenyl group, a piperazine ring, and a sulfonamide moiety, which collectively contribute to its high affinity for the 5-HT3 receptors located in the central nervous system and the gastrointestinal tract.
The primary mechanism of action involves the blockade of serotonin binding at these specific receptors. Since serotonin release during chemotherapy or radiation therapy triggers the vomiting reflex via vagal nerve stimulation, inhibiting this pathway effectively prevents both acute and delayed emesis. Unlike some older antiemetics, Azasetron demonstrates a favorable safety profile with minimal risk of extrapyramidal symptoms or sedation, making it suitable for patients requiring long-term supportive care. It is widely utilized in oncology settings, often administered intravenously or orally prior to cytotoxic treatment protocols. Clinical studies have consistently shown that Azasetron provides superior control over nausea compared to placebo and comparable efficacy to other established agents like ondansetron, though with a potentially longer duration of action in certain contexts. Beyond its oncological applications, research suggests potential utility in treating functional gastrointestinal disorders where serotonin dysregulation plays a role, although such uses remain largely investigational. As a generic medication in various markets, Azasetron remains a cornerstone in modern supportive cancer care, offering reliable relief from distressing gastrointestinal side effects associated with aggressive medical treatments. Its continued presence in global formularies underscores its importance in maintaining patient quality of life during critical therapeutic interventions.
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