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<h3>Overview</h3>
<p>Aprepitant is a neurokinin-1 (NK1) receptor antagonist used in chemotherapy-induced nausea and vomiting. Manufactured via multi-step organic synthesis, its molecular formula is <strong>C22H23ClN4O3</strong> with CAS number <strong>164580-37-8</strong>.</p>
<h3>Application</h3>
<ul>
<li>Oncology: Prevention of acute and delayed CINV in high-dose cisplatin regimens.</li>
<li>Gastroenterology: Management of postoperative nausea and vomiting.</li>
<li>Pediatrics: Dose-adjusted protocols for children undergoing emetogenic therapy.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated with strong CYP3A4 inducers like rifampin. Store in controlled temperature (< 25°C) with low humidity to prevent degradation. Medical supervision required due to drug-drug interaction risks.</p>