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Other Specialized Reagents

Apixaban intermediate G

Category:

Other Specialized Reagents

CAS NO:

536759-91-8

Standard:

ChP,In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Jianfeng Chemical Co., Ltd.

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Basic Info

CAS Number

536759-91-8

Pharmacopoeia

ChP,In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Product Description

CAS:	536759-91-8
MF:	C22H20N4O6
MW:	436.42
EINECS:	611-033-0
Product Categories:
Mol File:	536759-91-8.mol

AI Product Description

*The following content is generated by AI and is for reference only.

Apixaban Intermediate G is a critical pharmaceutical building block used in the synthesis of Apixaban, a potent and selective oral anticoagulant. While specific commercial catalogs may vary slightly in nomenclature, this intermediate generally refers to a key chiral precursor or functionalized derivative required for constructing the complex pyrazolopyridine core structure found in the final drug molecule. The exact molecular formula and CAS number depend on the precise synthetic stage; however, in standard industrial contexts, intermediates leading to Apixaban often involve substituted phenyl-pyrazole derivatives or amide coupling partners with specific stereochemistry. For instance, related precursors frequently possess formulas around C16H20N4O3S or similar variations depending on protecting groups, though definitive identification requires cross-referencing specific supplier specifications as "Intermediate G" is not a universal IUPAC name but rather an internal manufacturing code. The primary application of Apixaban Intermediate G lies within the active pharmaceutical ingredient (API) manufacturing sector. It serves as an essential reactant in multi-step organic synthesis protocols designed to produce high-purity Apixaban (Eliquis). This process typically involves nucleophilic substitution, amide bond formation, and cyclization reactions where the intermediate provides the necessary structural framework and chiral center. Pharmaceutical companies utilize this material to ensure the final product meets stringent regulatory standards set by agencies like the FDA and EMA regarding purity, enantiomeric excess, and impurity profiles. The use of such specialized intermediates allows manufacturers to optimize yield, reduce waste, and streamline production timelines compared to starting from basic raw chemicals. Furthermore, strict quality control measures are applied to these intermediates to prevent the introduction of toxicological risks into the final medication. As global demand for effective anticoagulants rises due to increasing rates of atrial fibrillation and venous thromboembolism, the supply chain stability for high-quality intermediates like Apixaban Intermediate G remains vital for continuous drug availability and patient safety worldwide.