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Products

Protein/Antigen/Polypeptide

Antifungal Drugs Ketoconazole CAS NO.65277-42-1

Category:

Protein/Antigen/Polypeptide

CAS NO:

65277-42-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Sinoway Industrial Co. Ltd

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Basic Info

CAS Number

65277-42-1

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

25kg/drum; 5kg/bag, 1kg/bag

Minimum Order Quantity

1kg

Delivery Cycle

7 days after payment

Product Description

Product Information

Ketoconazole Basic information

Product Name:	Ketoconazole
Synonyms:	,3-dioxolan-4-yl)methoxy)phenyl)-,cis-;fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral
CAS:	65277-42-1
MF:	C26H28Cl2N4O4
MW:	531.43
EINECS:	265-667-4

Melting point	146°C
Boiling point	753.4±60.0 °C(Predicted)
density	1.4046 (rough estimate)
refractive index	-10.5 ° (C=0.4, CHCl3)
Fp	9ºC
storage temp.	2-8°C
solubility	methanol: soluble50mg/mL
pka	pKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
form	Off-white solid
color	white to light yellow
optical activity	[α]20/D -1 to 1°, c = 4 in methanol
Water Solubility	Soluble in DMSO, ethanol, chloroform, water, and methanol.

Usage

Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.Target: CYP3A4 CYP24A1Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosteron levels, in men being treated for chronic mycotic infections [1]. Ketoconazole also is a cytochrome P450 inhibitor [2].Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver.[3] CYP24A1 inhibitor enhances antiproliferative effects, increases systemic calcitriol exposure, and promotes the activation of caspase-independent apoptosis pathway.