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CAS NO:
106685-40-9
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Basic Info
CAS Number
106685-40-9
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Adapalene is a third-generation synthetic retinoid widely utilized in dermatological medicine for the treatment of acne vulgaris. Chemically, its molecular formula is C₂₈H₂₆O₃, and it carries the CAS Registry Number 103476-88-2. Structurally, adapalene belongs to the naphthoic acid class of compounds, distinguishing it from earlier retinoids like tretinoin by offering greater chemical stability and reduced photodegradation. This stability allows it to remain effective when exposed to light, making it suitable for once-daily application without strict storage requirements regarding darkness.
The primary mechanism of action involves selective binding to nuclear retinoic acid receptors (RARs), specifically RAR-beta and RAR-gamma. By modulating these receptors, adapalene regulates keratinocyte differentiation and proliferation, effectively preventing the formation of microcomedones, which are the precursor lesions of acne. Furthermore, it possesses significant anti-inflammatory properties, reducing the recruitment of inflammatory cells to acne lesions and mitigating redness and swelling. Unlike some other retinoids that can cause severe irritation upon initial use, adapalene is formulated to be less irritating, often allowing patients with sensitive skin to tolerate therapy better. It is available in various topical formulations, including gels, creams, and lotions, typically at concentrations ranging from 0.1% to 0.3%. Clinical studies have consistently demonstrated its efficacy in treating both inflammatory papules and pustules as well as non-inflammatory comedones. While generally safe for most adults, it is contraindicated during pregnancy due to potential teratogenic risks associated with retinoid classes. Overall, adapalene represents a cornerstone therapy in modern dermatology, offering a balanced profile of efficacy, stability, and tolerability for managing moderate to severe acne.
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