Acetylated sodium hyaluronate (AcHA) is a derivative of hyaluronic acid obtained by acetylation reaction of natural moisturizing factor sodium hyaluronate (HA). Due to the introduction of a large number of acetyl groups, the lipophilicity and lipophilicity of acetylated hyaluronate salts are greatly improved. Acetylated sodium hyaluronate is more efficient in moisturizing, repairing skin barriers, increasing skin elasticity, and has better transdermal properties and resistance to hyaluronidase compared to traditional sodium hyaluronate.