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CAS NO:
59-66-5
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Basic Info
CAS Number
59-66-5
Pharmacopoeia
ChP
Grade
In-house Standards
Is Manufacturer
YES
Packaging & Delivery
Minimum Order Quantity
Any
Delivery Cycle
Negotiable
Product Description
Reference Standards &Impurity
AI Product Description
*The following content is generated by AI and is for reference only.
Acetazolamide, chemically known as 5-acetamido-1,3,4-thiadiazole-2-sulfonamide, is a widely utilized carbonic anhydrase inhibitor with the molecular formula C4H6N4O3S2 and the CAS registry number 59-66-5. First synthesized in the mid-20th century, this sulfonamide derivative has established itself as a cornerstone therapeutic agent across multiple medical disciplines due to its unique mechanism of action. By inhibiting the enzyme carbonic anhydrase, Acetazolamide disrupts the reversible hydration of carbon dioxide, thereby reducing the production of aqueous humor in the eye, altering cerebrospinal fluid dynamics, and inducing metabolic acidosis through renal bicarbonate excretion.
Clinically, Acetazolamide serves diverse purposes ranging from ophthalmology to neurology and pulmonology. In eye care, it is a primary treatment for glaucoma, effectively lowering intraocular pressure to prevent optic nerve damage. For neurological conditions, it plays a critical role in managing acute mountain sickness by accelerating acclimatization at high altitudes and treating certain forms of epilepsy, particularly absence seizures and myoclonic seizures. Furthermore, it is employed to correct metabolic alkalosis and manage periodic paralysis associated with electrolyte imbalances. The drug is typically administered orally in tablet or capsule form, though intravenous formulations exist for emergency settings. While generally well-tolerated, common side effects include paresthesia, fatigue, and metallic taste, while serious adverse reactions may involve kidney stones or severe allergic responses. Its versatility makes it indispensable in both hospital and field medicine, offering a reliable solution for fluid regulation and pH balance disorders. Ongoing research continues to explore its potential in treating other conditions involving fluid retention or pH dysregulation, solidifying its status as a vital pharmaceutical tool in modern healthcare systems worldwide.
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