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Other Specialized Reagents

5-Chloro-2-methoxybenzenesulfonyl chloride

Category:

Other Specialized Reagents

CAS NO:

22952-32-5

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Show Room

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Basic Info

CAS Number

22952-32-5

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

5-Chloro-2-methoxybenzenesulfonyl chloride、22952-32-5

AI Product Description

*The following content is generated by AI and is for reference only.

5-Chloro-2-methoxybenzenesulfonyl chloride is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the chemical formula C7H6Cl2O3S and CAS Registry Number 14098-67-4, this compound serves as a critical building block in medicinal chemistry due to its unique reactivity profile. The molecule features a benzene ring substituted with a chlorine atom at the fifth position, a methoxy group at the second position, and a highly reactive sulfonyl chloride functional group. This specific arrangement allows chemists to introduce diverse nitrogen-containing side chains through nucleophilic substitution reactions, facilitating the construction of sulfonamide derivatives which are prevalent in drug discovery. The primary application of 5-chloro-2-methoxybenzenesulfonyl chloride lies in the preparation of sulfa drugs, kinase inhibitors, and various bioactive scaffolds. Its electron-withdrawing chloro substituent enhances the electrophilicity of the sulfur center, making it particularly effective for coupling with amines under mild conditions to form stable sulfonamide bonds. Furthermore, the presence of the methoxy group can influence the lipophilicity and metabolic stability of the final therapeutic agents, offering researchers a valuable tool for optimizing structure-activity relationships (SAR). In agrochemical research, this reagent aids in developing novel herbicides and fungicides that target specific enzymatic pathways in pests while minimizing environmental impact. Handling this substance requires strict adherence to safety protocols, as sulfonyl chlorides are moisture-sensitive and can release corrosive hydrogen chloride gas upon contact with water or humid air. Proper storage in a cool, dry environment within sealed containers is essential to maintain purity and prevent degradation. As a versatile precursor, 5-chloro-2-methoxybenzenesulfonyl chloride continues to play an indispensable role in advancing chemical innovation across multiple sectors, supporting the development of next-generation therapeutics and agricultural solutions. Its availability from major chemical suppliers ensures accessibility for both academic laboratories and industrial manufacturing processes seeking efficient routes to high-value sulfonamides.