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Other Specialized Reagents

5-bromopyridine-3-carbonyl chloride

Category:

Other Specialized Reagents

CAS NO:

39620-02-5

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Asia

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Capot Chemical Co., Ltd.

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Basic Info

CAS Number

39620-02-5

Pharmacopoeia

In-house Standards

Grade

pharmaceutical grade

Is Manufacturer

YES

Packaging & Delivery

Packaging Specification

1kg、5kg、25kg

Product Description

5-bromopyridine-3-carbonyl chloride、39620-02-5

AI Product Description

*The following content is generated by AI and is for reference only.

5-Bromopyridine-3-carbonyl chloride is a versatile and highly reactive heterocyclic acylating agent widely utilized in organic synthesis, pharmaceutical development, and materials science. With the chemical formula C6H3BrClNO and a CAS registry number of 107498-23-5, this compound serves as a crucial intermediate for constructing complex nitrogen-containing architectures. The molecule features a pyridine ring substituted with a bromine atom at the 5-position and an acid chloride functional group at the 3-position, endowing it with dual reactivity sites that facilitate diverse chemical transformations. Primarily employed as an electrophilic building block, 5-bromopyridine-3-carbonyl chloride reacts readily with nucleophiles such as amines, alcohols, and hydrazines to form amides, esters, or hydrazides. This property makes it indispensable in the synthesis of bioactive compounds, including kinase inhibitors, antiviral agents, and fluorescent probes. The presence of the bromine substituent allows for further cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, enabling the attachment of various aryl or alkyl groups to generate sophisticated molecular scaffolds. Consequently, it plays a pivotal role in medicinal chemistry campaigns aimed at optimizing lead compounds for enhanced potency and selectivity. In industrial applications, this reagent is used to produce specialized agrochemicals and advanced polymers where specific electronic properties are required. Due to its moisture sensitivity and corrosive nature, handling requires strict adherence to safety protocols, typically involving inert atmospheres and anhydrous conditions to prevent hydrolysis into the corresponding carboxylic acid. Its high purity grade ensures reliable performance in multi-step synthetic sequences, making it a preferred choice for researchers developing novel therapeutics. As the demand for targeted drug discovery grows, the utility of 5-bromopyridine-3-carbonyl chloride remains significant, bridging fundamental organic chemistry with practical biomedical solutions. Researchers continue to explore its potential in creating next-generation heterocycles that address unmet medical needs through precise structural modification.